Spatially Resolved Transcriptomics
Service
Experiment:
In September 2019, 10x Genomics launched the first commercial spatially resolved transcriptomic technique: Spatial Transcriptomics, developed by scientists from Karolinska Institute, Sweden. We have cooprated with the agency company of 10x Genomics. The experiment can be performed in our center.
Data analysis:
The center has established the data analysis pipeline, and developed the online data visualization platform: SpatialDB (https://www.spatialomics.org/SpatialDB/)
Materials
1.Spatial Research Lab: https://www.spatialresearch.org/
2.Spatial Transcriptomics in 10x Genomics: https://spatialtranscriptomics.com/
3.Introducing the Visium Spatial Gene Expression Solution: PDF
4.Visium Spatial Protocols – Tissue Preparation Guide: PDF
Published Papers
| PMID | Title | Journal | Year |
|---|---|---|---|
| 27365449 | Visualization and analysis of gene expression in tissue sections by spatial transcriptomics | Science | 2016 |
| 29021611 | Spatial detection of fetal marker genes expressed at low level in adult human heart tissue | Sci Rep | 2017 |
| 29925878 | Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity | Nat Comm | 2018 |
| 30154148 | Spatially resolved transcriptomics enables dissection of genetic heterogeneity in stage III cutaneous malignant melanoma | Cancer Res | 2018 |
| 30948552 | Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis | Science | 2019 |
| 31501547 | High-definition spatial transcriptomics for in situ tissue profiling | Nature Methods | 2019 |