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About
Mouse-SNPs :
SNPs in transcription factor binding sites (TFBS) in promoters of lncRNA genes. TFBS were identified from ChIP-seq data and were also predicted by using TF position weight matrix from JASPAR database. SNPs in TFBS might affect the transcription of lncRNAs.
SNPs in TFBS that were co-located with promoters of lncRNA genes in spatial organization. We combined TFBS with genome spatial contacts, and found that TFBS were co-located with the promoter of lncRNA genes in spatial organization. SNPs in these TFBS might affect transcription of lncRNAs through long-range looping interactions.
SNPs in m6A modification sites on lncRNAs. m6A modification is the most common and abundant modification on RNA molecular. SNPs might affect the biological function of lncRNAs through altering m6A modification.
Synonymous and nonsynonymous SNPs in lncRNAs, which were found to be able to encode peptides. We collected the information of peptides encoded by lncRNAs from literatures, and identified the SNPs that might alter peptide sequences.
Molecular mechanism of SNPs affecting transcription, modification and translation of lncRNA genes:
SNP
Chr
Position
Ref
Alt
DNA_3D
ChIPSeq
Predicted_TFBS
m6A
Peptide
dbSNP
SNP
Chr
Position
Ref
Alt
DNA_3D
ChIPSeq
Predicted_TFBS
m6A
Peptide
dbSNP