研究工作
当前位置:首页 > 研究工作 > 发表论文
发表论文

[Cell Stem Cell. 2015] The long noncoding RNA lncTCF7 promotes self-renewal...

发表日期:2017-06-27 20:25:56

 2015 Apr 2;16(4):413-25. doi: 10.1016/j.stem.2015.03.003.

The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling.

Wang Y1He L2Du Y1Zhu P1Huang G3Luo J4Yan X1Ye B1Li C1Xia P1Zhang G1Tian Y4Chen R5Fan Z6.

Abstract

Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an lncRNA-based Wntsignaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that lncRNAs can play in tumor growth and propagation.


联系我们
Copyright © 2015-2017 健康大数据研究中心
地址:北京市朝阳区大屯路15号 100101 电话:010 64888546